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Colorado Buffaloes vs USC Trojans odds: College Football September 29, 2023

This Saturday, USC Trojans are gearing up to face the Colorado Buffaloes as both Dion Sanders and the Buffaloes rebound from their first losses of the season, USC travels to Colorado this Saturday after a consecutive road trip last week. The Trojans played their first road game of the season last week, emerging with a 42-28 victory over Arizona State, improving to 4-0. Colorado, on the other hand, started the season with three straight wins but suffered a significant setback, losing 42-6 to Oregon last week. The Buffaloes will take the field again without star quarterback Jaren Hunter, who was injured last week.

Kickoff is scheduled for noon ET. The latest USC vs. Colorado odds see the Trojans as 22.5-point favorites, with a total points line set at over/under 73. Before making your pick for Colorado vs. USC, you’ll want to see the college football predictions and betting advice.

This projection model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated over $2,500 for $100 players on its top-rated college football picks against the spread. It’s also been a standout on its moneyline picks, finishing last season with a 130-84 overall record on all top-rated college football picks. Moreover, it also enters Week 6 of the 2023 college football season on a strong 17-9 run on top-rated college football picks against the spread.

Now, the model has its sights set on USC vs. Colorado and has uncovered its picks and projections. We can tell you that the model is leaning under, and it’s also generated a strong point-spread pick that hits in well over 50 percent of simulations.

Note: This video is taken to “SportsLine” YouTube Channel

Why USC could cover

USC quarterback Caleb Williams and company will face a Colorado defense that ranks dead last in the nation (269.2 passing yards allowed per game). They will be tasked with exploiting the Buffaloes’ defense, which allowed just 217 passing yards and three touchdowns in the first half alone against Oregon last week.

In addition, the Buffaloes have struggled to protect the quarterback position this season. With a porous offensive line that includes multiple transfers and a true freshman, Colorado surrenders 5.75 sacks per game, which ranks second to last among all 130 FBS programs, trailing only Old Dominion (6.50). Colorado’s two-way star Shedeur Sanders will also be absent from this game as he is recovering from a broken collarbone.

Why Colorado could cover

Colorado’s performance against Oregon was disastrous, but the Buffaloes bounced back strongly against a ranked opponent. During the first two weeks of the season, they defeated both TCU and Nebraska, emerging as a top team in the early going. While USC’s offense has been potent, the Trojans have been ordinary on the defensive side of the ball. They allowed San Jose State and Arizona State to score 28 points each, failing to cover the spread in either game.

The Buffaloes also have an offense that could capitalize, with each of their first three outings seeing them score 35 or more points. Junior quarterback Shedeur Sanders has amassed 1,410 passing yards, 11 touchdowns, and one interception, while running back Dylan Edwards boasts a per-carry average of 5.6 yards. USC hasn’t met market expectations since the end of last season and has covered the spread in just two of its last six games. See which team to pick here.

How to make USC vs. Colorado picks

This model is leaning under the point total, and it also says one side of the spread hits in well over 50 percent of simulations.

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